Dementia and Posttraumatic Stress Disorder: A Long-Term Study
The aim of this paper is to propose a study to be conducted using neuropsychological assessments to determine whether the cause of dementia in elderly adults is due to a neurodegenerative condition or to an untreated mood disturbance as a result of Posttraumatic Stress Disorder (PTSD). This study will also examine the short- and long-term efficacies of 4 treatments for PTSD in participants living in an unsafe, unstable region amidst ongoing violence. The participants randomly selected will be 100 Israelis and Palestinians with suspected dementia and diagnoses of past or current PTSD. After baseline neuropsychological assessment, participants will be matched into 4 treatment groups including 3 experimental groups receiving Cognitive Behavior Therapy (CBT}, Propranalol, or a combination of CBT and Propranalol, and 1 control group receiving a placebo. Follow-up studies will be conducted after 1, 3, and 6 months, and after 1 and 5 years using neuropsychological assessments and the post-traumatic stress disorder interview (PTSD-1}, the Beck Depression Inventory-11 (BDI-11), and the Beck Anxiety Inventory (BAI) to evaluate a neurodegenerative or emotional basis for dementia and to assess the efficacy of each treatment for PTSD.
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