Chronic Treatment of LAAM and Buprenorphine in Heroin and Buprenorphine Discriminating Pigeons
Duiker, Nicklaus J.
As abuse of opioids, such as heroin, are growing concerns; even more important are therapies for drug cessation. In human patients there has been evidence that a therapy called "substitution therapy" has helped individuals stop abusing opioids. This therapy uses LAAM (a methadone derivative) and buprenorphine, which reduce the addiction to heroin. The goal of the study was to test whether LAAM or buprenorphine produces cross-tolerance to the subjective discriminate stimulus effects of heroin. A chronic treatment of5.6 mg/kg of LAAM and 5.6 mg/kg of buprenorphine were given chronically to pigeons for seven days. Dose-effect curves were determined to see if cross-tolerance to heroin was produced in pigeons. The evidence of the data is that LAAM and buprenorphine do not produce cross-tolerance to the subjective discriminate stimulus effects of heroin.
iv, 20 p.
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