Chronic Treatment of LAAM and Buprenorphine in Heroin and Buprenorphine Discriminating Pigeons
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Authors
Duiker, Nicklaus J.
Issue Date
2001
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
As abuse of opioids, such as heroin, are growing concerns; even more important
are therapies for drug cessation. In human patients there has been evidence that a therapy called "substitution therapy" has helped individuals stop abusing opioids. This therapy uses LAAM (a methadone derivative) and buprenorphine, which reduce the addiction to heroin. The goal of the study was to test whether LAAM or buprenorphine produces cross-tolerance to the subjective discriminate stimulus effects of heroin. A chronic treatment of5.6 mg/kg of LAAM and 5.6 mg/kg of buprenorphine were given
chronically to pigeons for seven days. Dose-effect curves were determined to see if
cross-tolerance to heroin was produced in pigeons. The evidence of the data is that
LAAM and buprenorphine do not produce cross-tolerance to the subjective discriminate
stimulus effects of heroin.
Description
iv, 20 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.