Dosing Human Dermal Fibroblasts with Diesel Particulate Matter Leads to an Increase in Oxidative Stress
Loading...
Authors
Shansky-Genovese, Isabella
Issue Date
2022
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Air pollution is a major problem facing the world today. One
major pollutant is fine particulate matter (PM2.5) which is
classified as any particle with a 2.5ug diameter, typically diesel
particulate matter (DPM) and soot. With such small particle sizes,
it is very easy for DPM to enter the body and impact the
cardiovascular system (Wang et al., 2015), immune system (Wei
and Tang, 2018), lungs (Liu et al., 2017), and even the nervous
system (Shou et al., 2019).
There are two major points of contact for these particles: through
the airway and through the skin (Piao et al., 2018). Since the skin
is the body’s largest organ, it has a large surface area that is
exposed to air pollutants such as DPM. Learning how DPM
impacts the skin will help to understand how these health issues
can be avoided. In this study, I aim to look at the viability and
change in gene expression of inflammation and collagen genes in
NHDFs when treated with DPM. I expect to find an increase in
inflammation (IL1A), tissue remodeling (MMP9), and antioxidant
genes (NQO1 and NFE2L2), as well as a decrease in collagen
(COL1A1).
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.