Effects of Hippocampal, Amygdala, Superior Temporal Sulcul, and Temporal Lobe Volumes on Social Functioning in Children with Velocardiofacial Syndrome
Loading...
Authors
Rowe, Steven L.
Issue Date
2010
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Velocardiofacial syndrome (VCFS) is a relatively common genetic disorder produced by a
deletion of DNA in the q 11.2 region of chromosome 22. ·It causes a wide range of symptoms in
those afflicted, including physical, cognitive, and social deficits. In the present study, MRI was
used to scan the brains of six children with VCFS and six controls to determine if volumetric
differences existed in the amygdala, temporal lobe, superior temporal· sulcus, and hippocampus
between the two groups. These volumes were then correlated with subscales of the child
behavior checklist (CBCL). It was found that the VCFS group had significantly larger mean
amygdala volume than controls, as well as significantly smaller mean temporal lobe, superior
temporal sulcal, and right hippocampal volume. Unexpectedly, te.mporallobe and hippocampal
volUme in the VCFS group correlated positively with the anxiety/depression subscale of the
CBCL, and superior temporal sulcal volume correlated positively with the thought problems
subscale. No other correlations were significant. These findings demonstrate specific structural
deficits in the brains of people with VCFS that may be implicated in the social functioning of
these individuals.
Description
v, 43 p.
Citation
Publisher
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.