Neurochemical Changes that Result from Cocaine Dependence in Young Users

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dc.contributor.advisorBatsell, W. Robert, 1963-
dc.contributor.advisorJohanson, Chris-Ellyn
dc.contributor.authorBarasch, Megan E.
dc.descriptionvi, 92 p.en_US
dc.description.abstractThis paper is a review of research and a proposed study on the neurochemical effects of cocaine dependence. Some research has shown cocaine to have adverse physiological, psychological, and neurological problems. Previous research found that certain areas of the brain show concentration changes of N-acetyl-aspartate (NAA), creatine (Cr), and myo-inositol (ml) as a result of cocaine dependence. A decrease in NAA levels has been linked to neuronal damage and dysfunction. An increase in Cr and ml has been linked to neuronal damage and abnormality in cell membranes respectively. This paper proposes using magnetic resonance spectroscopy (MRS) to investigate the neurochemical changes throughout the entire brain. It is hypothesized that NAA levels will decrease and that Cr and ml levels will increase in cocaine addicted participants. Cocaine dependent (CD) participants must fit criteria only for cocaine dependence as described by the DSM IV. Neurochemical data obtained through MRS of CD participants will be compared with matched control participants. Understanding the neurochemical effects of cocaine will aid in diagnoses and improve the efficacy of treatment of cocaine addiction.en_US
dc.description.sponsorshipDepartment of Psychiatry and Behavioral Neurosciences. School of Medicine. Wayne State University. Detroit, Michigan.
dc.relation.ispartofKalamazoo College Psychology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Psychology.;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleNeurochemical Changes that Result from Cocaine Dependence in Young Usersen_US