Neurochemical Changes that Result from Cocaine Dependence in Young Users
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Authors
Barasch, Megan E.
Issue Date
2000
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
This paper is a review of research and a proposed study on the neurochemical effects of
cocaine dependence. Some research has shown cocaine to have adverse physiological,
psychological, and neurological problems. Previous research found that certain areas of
the brain show concentration changes of N-acetyl-aspartate (NAA), creatine (Cr), and
myo-inositol (ml) as a result of cocaine dependence. A decrease in NAA levels has been
linked to neuronal damage and dysfunction. An increase in Cr and ml has been linked to
neuronal damage and abnormality in cell membranes respectively. This paper proposes
using magnetic resonance spectroscopy (MRS) to investigate the neurochemical changes
throughout the entire brain. It is hypothesized that NAA levels will decrease and that Cr
and ml levels will increase in cocaine addicted participants. Cocaine dependent (CD)
participants must fit criteria only for cocaine dependence as described by the DSM IV.
Neurochemical data obtained through MRS of CD participants will be compared with
matched control participants. Understanding the neurochemical effects of cocaine will
aid in diagnoses and improve the efficacy of treatment of cocaine addiction.
Description
vi, 92 p.
Citation
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License
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