Serotonin Receptor Antagonist Has a Neuroprotective Effect in a C. elegans Neurodegenerative Model

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Authors
Harding, Madeline
Issue Date
2022
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en_US
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Abstract
Neurodegenerative diseases are characterized by the progressive and abnormal death of neurons. Glutamate excitotoxicity is known to be a common mechanism leading to neuronal death in many neurodegenerative diseases. Antagonizing glutamate receptors with drugs such as MK-801 in vivo at high dosages causes damaging side effects, thus a new model for modulating extracellular glutamate is needed. Serotonin has been shown to regulate glutamate transmission. 5-HPEC is a serotonin receptor was investigated for its neuroprotective effects in Caenorhabditis elegans (C. elegans).
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1 Broadside. 48"W x 36"H
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Kalamazoo, Mich. : Kalamazoo College
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U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
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