Serotonin Receptor Antagonist Has a Neuroprotective Effect in a C. elegans Neurodegenerative Model
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Authors
Harding, Madeline
Issue Date
2022
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Neurodegenerative diseases are characterized by the
progressive and abnormal death of neurons.
Glutamate excitotoxicity is known to be a common
mechanism leading to neuronal death in many
neurodegenerative diseases.
Antagonizing glutamate receptors with drugs such as
MK-801 in vivo at high dosages causes damaging side
effects, thus a new model for modulating extracellular
glutamate is needed.
Serotonin has been shown to regulate glutamate
transmission.
5-HPEC is a serotonin receptor was investigated for its
neuroprotective effects in Caenorhabditis elegans (C.
elegans).
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.