Study of Nicotinic, Muscarinic, and Ionotropic Glutamate Receptors in Kindled Rat Brain and Correlation with Behavior During Kindling in Preparation for Autoradiography
Post-traumatic epilepsy (PTE) is a common medical condition in people who have suffered severe head injuries. We are using periodic, low-level electrical stimulation of rat brain to mimic biochemical changes that occur in the brains of patients with PTE. During this process, known as kindling, no behavioral effects are observable in the first several days; however, an electrical effect called the afterdischarge (AD) is seen. The AD is necessary for kindling to develop seizures. With repeated stimulations, increasing behavioral and electrical seizures are seen. I examine patterns in behavioral activity during the kindling process in Sprague-Dawley rats, as well as comparing this information with an older kindling study. Preliminary assays are done to elucidate an effective method for getting accurate results in autoradiography. Using these methods, we will look for changes in the nicotinic, muscarinic, ionotropic glutamate receptor densities in specific regions of kindled rat brain.
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