Opioid Dependent Reductions in Selected Ambient Temperature Following Acute, Intermittent Hypoxia
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Authors
Carney, Karen
Issue Date
1993
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Exposure to non-lethal acute hypoxia (hypoxic conditioning - HC)
increases tolerance to subsequent hypoxia in mice. Naloxone reverses this
increase in tolerance, and attenuates a decrease in body temperature (Tb). We
determined whether He causes a regulated drop in the thermoregulatory set
point of mice, as indicated by reduced Tb's and behavioral preference for
lower ambient temperatures (Ta). We also tested for naloxone reversibility.
Naloxone (0.1, 1.0 mg/kg i. p.) or saline (0.3 ml i. p.) was injected 5 min prior
to hypoxic or sham conditioning (Se), after which Tb and Ta were monitored
in a thermal gradient for 30 min at 30 sec intervals. He decreased Tb for all
time points and decreased selected Ta during the first 10 min following
conditioning. Naloxone attenuated the decrease in Tb, and reversed the
decrease in selected Ta. These data suggest that the HC protocol decreases
thermoregulatory set-point, and that the process leading to this decrease
involves endogenous opioids as indicated by naloxone reversibility.
Description
iv, 24 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.