Nod2 Receptor Role in TNF-α Secretion Response to Pseudomonas Aeruginosa

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Authors
Stoolman, Joshua
Issue Date
2008
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en_US
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Abstract
•Mechanisms of the innate immune response serve as the first line of defense against infection and coordinate the adaptive immune response •Pathogen Associated Molecular Patterns (PAMPs) are detected by a group of receptors called Pattern Recognition Receptors (PRRs) that respond by upregulating secretion of pro-inflammatory cytokines and chemokines such as TNF-α and KC (human IL-8) •PRR group members such as Toll-like Receptors (TLRs) and Nod-like Receptors NLRs detect the presence of PAMPs •The receptors relevant to this study are sensitive to different molecules associated with bacterial cell walls •TLR4: Type I transmembrane receptor for Lipopolysaccharide (LPS), a major component of gramnegative bacterial cell walls •Nod1: cytosolic detection of meso-Diaminopimelic Acid (meso-DAP) a residue found in the cell walls of most gram negative bacteria •Nod2: cytosolic detection of Muramyl Dipeptide (MDP) a part of the peptidoglycan (PGN) molecule found on both gram-positive and gram-negative bacteria •Pseudomonas aeruginosa is an opportunistic gram-negative bacteria that causes severe infections in immunocompromised patients
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Kalamazoo, Mich. : Kalamazoo College.
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