Cux1 Regulation on PTCH1 gene in Polycystic Kidney Disease’s Progression
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Authors
Wee, Zhi Tian
Issue Date
2022
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Autosomal Dominant Polycystic Kidney Disease
(ADPKD) is a hereditary disease that causes fluid-filled
cysts that affects 1:500-1:1000 people all over the world.
The Galapagos cormorant is a flightless bird that was
found without the Cux1 gene, making it flightless.
The Galapagos cormorant is how researchers found the
four target proteins to focus on in ADPKD research.
ADPKD is caused by mutation in PKD1 or PKD2 gene.
PKD1 and PKD2 encodes a product called polycystin-1
(PC1) and polycystin-2 (PC2).
Mutations in PKD1 or PKD2 can cause abnormalities
in fluid secretion, apoptosis, gene expression, and cell
polarity.
A gene called Patched1 is studied through the lens of
ADPKD to determine how it affects the disease.
Multiple mice with different gene expressions were used
to measure Cux1 expression and cilia length via
immunofluorescence and western blots in their kidney
tissue to detect Patched1 proteins.
Primary cilia is crucial because it is within the Hedgehog
pathway (Hh) where this signaling pathway regulates cell
proliferation, tissue homeostasis, cell development.
The disruption of the primary cilium will cause diseases
called ciliopathies.
The Notch pathway regulates Cux1, and the disruption of
this pathway can cause tubule dilation or RBPJ protein
missing which will increase cyst formation.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.