Development of a Carrier Which Induces Endochondral Bone Differentiation Activity whith Osteogenic Protein In Vivo
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Authors
Richmond, Emilie A.
Issue Date
1988
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Subcutaneous implantation of osteogenic Protein (OP) with a
collagenous bone matrix induces endochondral bone differentiation
in vivo. The OP with biological activity can be purified from
any mammalian species, but successful bone induction requires the
presence of a species specific collagenous bone matrix. In order
for the OP to be useful for human application, a chemically
defined, biologically acceptable carrier is necessary. certain
commercially available ceramics, biopolymers, and hypoimmunogenic
bovine skin and tendon collagens were implanted with OP in vivo
to test for their ability to support bone growth. In addition,
the modulating role of two growth factors, (designated GFl and
GF2 due to proprietary rights) which are normally present in
bone, was also studied. The results demonstrate that ceramics,
biopolymers and bovine skin collagens are ineffective in inducing
bone in vivo. studies on the growth factors suggest that they
appeared to have a modulating role on bone differentiation in
vivo.
Description
v, 30 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.