Morphological effect of immobilization on collagen fibrils in rat tail tendons
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Authors
Frank, Katherine J.
Issue Date
2004
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Fibril Size Decreases:
•With disease – Cranial cruciate ligament (CrCL)
insufficiency in dogs (Zachos, et al. 2002).
•After exposure of rabbit medial collateral ligaments
(MCL) to bacterial collagenase (Cunningham, et al.
1997).
• In scar tissue formed after surgery in conjunction
with type III collagen production (Shino, et al.
1995).
Purpose
•The purpose of this study was to determine if collagen fibril (Fig. 1) morphology (size,
density) changes when tendons are deprived of stress.
Stress Deprived Tendons:
•Have increased collagenase (MMP-1) production that correlates to decrease in strength and
stiffness (Arnoczky, et al. 2003 and Lavagnino, et al. 2003 ).
Hypothesis
•We hypothesized that collagen fibril diameter would decrease in stress deprived tendons,
and that this would correlate to a decrease in stiffness of the tendons
Description
1 broadside : ill.
Diebold Scholar
Diebold Scholar
Citation
Publisher
Kalamazoo College