Effects of Selective Myostatin Inhibitor PAH-A on Broiler Skeletal Muscle Production

dc.contributor.authorSnider, Brittany A.
dc.description.abstractA fivefold increase in worldwide meat production over the past 50 years has fueled research in muscle physiology toward the development of methods to increase skeletal muscle growth in agricultural animals. A breakthrough in the exploration of muscle production occurred in 1997 with the identification of myostatin, a negative regulator for skeletal muscle development. Mutations in the myostatin gene have been shown to increase skeletal muscle growth in several species including mice, cattle, and humans. A natural mutation in this gene results in the double muscling phenotype of Belgian Blue cattle (Figure 1). Some strategies proven to repress myostatin function, such as the administration of myostatin-specific antibodies or the use of a soluble activin type II receptor (ActRIIBFc), reduce the binding affinity of myostatin to its receptor, activin receptor type II B (ActRIIB). Pfizer Animal Health Compound A (PAH-A), a selective myostatin inhibitor, also impedes the attachment of myostatin to ActRIIB. The effectiveness of PAH-A in augmenting skeletal muscle growth has not previously been described in poultry. The ultimate goal of our study was to investigate the effects of PAH-A on skeletal muscle production in broilers. We hypothesized that in ovo administration of PAH-A would increase body mass gain (BMG) and muscle fiber cross-sectional-area (CSA) of standard broilers at post-hatch days 3 (D3) and 14 (D14).en
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2008.
dc.publisherKalamazoo, Mich. : Kalamazoo College.
dc.relation.ispartofKalamazoo College Diebold Symposium Presentations Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleEffects of Selective Myostatin Inhibitor PAH-A on Broiler Skeletal Muscle Productionen