The Effect of Circulating Antibody on Cutaneous Herpes Infection in Hairless Mice
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Authors
Underwood, Gary E.
Issue Date
1969
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The role of antibodies in inhibition of virus infections has been examined by many people. This search has
extended to herpes virus in mice. Peak antibody strengths
in response to subcutaneous injections of live herpes virus
in haired white mice was studied by Sydiskes and Schultz.
In an earlier series of tests Sydiskis and Schultz had
examined the development of cutaneous lesions in white mice
in response to subcutaneous infections of varying strengths
of herpes virus solutions. We felt there was value in a
study of the effect of this observed antibody production on
a subsequent cutaneous viral challenge.
Underwood has recently instigated research with
cutaneous herpes infections in hairless mice. Lesion progress
was more easily observed. It was free from the
considerations of trauma during hair removal and hair regrowth
which complicated the results of Sydiskis and Schultz.
Provided with an animal suitable for observation, it
was possible to examine the effect of antibodies on the
cutaneous herpes infection. Two methods of introduction of
antibodies into the mouse were examined: inoculation with
herpes immune serum and inoculation with a sub-lethal dose
of live herpes virus to stimulate antibody production. The
mice were then challenged cutaneously. This paper reports
the effects of these different sources of circulating
antibody on the growth of the cutaneous herpes lesion.
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Description
iii, 16 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.