Cytosine ß-D-Arabinofuranoside Drug Sensitivity in Down Syndrome Lymphoblastoid Cell Lines
Bartnik, Catherine Michelle
Down syndrome (DS) individuals have an increased risk of developing acute myeloid leukemia (AML) at a young age. A remarkable feature of DS AML is the high event free survival (EFS) rate in comparison to non-DS AML individuals. It has been postulated that this positive prognosis is the result of a high-dose protocol utilizing the chemotherapeutic agent, cytosine ß-Darabinofuranoside (Ara-C). The sensitivity of DS and non-malignant non-DS lymphoblastoid cells (LCLs) to Ara-C is not known and is an area of scientific interest. This study compares sensitivity to Ara-C in LCLs derived from DS individuals to those from individuals without DS. Analysis of the cohort (n= 124) found DS LCLs to be significantly more sensitive to Ara-C at the 5 μM concentration, and with respect to IC50 value and AUC value. These results confirm the presence of a non-tumor genetic factor influencing drug sensitivity in DS individuals. The factor, if found, could greatly change the treatment of non-DS AML individuals
Kalamazoo, Mich. : Kalamazoo College.
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