Overexpression of O-linked N-Acetylglucosamine Transferase (OGT) and GlcNAc Proteins in Female Systemic Lupus Erythematosus Patients

dc.contributor.authorVerbeek, Stephanie
dc.date.accessioned2013-05-03T18:36:37Z
dc.date.available2013-05-03T18:36:37Z
dc.date.issued2013
dc.descriptionMicrosoft PowerPoint presentation slidesen_US
dc.description.abstractThe crucial functions of the CD4+ T cells become hindered when CD4+ T cells are hypomethylated. CD4+ T cells stimulate the autoimmune response and are important for helping with the production of antibodies. OGT enables the addition of O-GlcNAc to threonine and serine residues of proteins. OGT is an X-linked gene and mRNA OGT was found overexpressed in T cells from SLE females and experimentally demethylated T cells in the Richardson lab. This finding makes OGT an important molecule to investigate because the wide range of targets that could be affected by its overexpression, the targets have important impact on cellular signaling, and its overexpression could be related with the female preponderance in SLE.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2013en_US
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10920/28669
dc.language.isoen_USen_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleOverexpression of O-linked N-Acetylglucosamine Transferase (OGT) and GlcNAc Proteins in Female Systemic Lupus Erythematosus Patientsen_US
dc.typePresentationen_US
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