Overexpression of O-linked N-Acetylglucosamine Transferase (OGT) and GlcNAc Proteins in Female Systemic Lupus Erythematosus Patients
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Authors
Verbeek, Stephanie
Issue Date
2013
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
The crucial functions of the CD4+ T cells become hindered when CD4+ T cells are hypomethylated. CD4+ T cells stimulate the autoimmune response and are important for helping with the production of antibodies. OGT enables the addition of O-GlcNAc to threonine and serine residues of proteins. OGT is an X-linked gene and mRNA OGT was found overexpressed in T cells from SLE females and experimentally demethylated T cells in the Richardson lab. This finding makes OGT an important molecule to investigate because the wide range of targets that could be affected by its overexpression, the targets have important impact on cellular signaling, and its overexpression could be related with the female preponderance in SLE.
Description
Microsoft PowerPoint presentation slides
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.