Investigation of kinase/s to determine the catalytic activity of serum- and glucocorticoid- inducible kinase 1 (SGK1) at a site regulated by drugs of abuse
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Authors
Huisken, Briana L.
Issue Date
2018
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Addiction is a serious and chronic disease that causes
alterations in the brain reward circuit, specifically in the
mesolimbic dopamine reward pathway. This pathway
encompasses the ventral tegmental area (VTA), nucleus
accumbens (NAc), medial prefrontal cortex, amygdala
and the hippocampus. Specifically, the VTA-NAc
pathway has been associated with an increase in
activation due to drugs of abuse, such as cocaine and
morphine. Although both of these drugs lead to an
increased activation of this pathway, they act in different
manners. For instance, cocaine binds to dopamine
transporters, preventing the reuptake of dopamine,
permitting it to continually bind to the receptors. This
ultimately leads to continual activation of this pathway,
thereby eliciting a rewarding feeling. On the other hand,
morphine works to decrease the inhibitory response from
interneurons, while increasing the excitatory response.
This leads to the release of more dopamine into the
NAc, producing the same euphoric feeling as cocaine.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.