Exploring Ubiquitination in Cancer Regulation
Ubiquitylation is a post-translational modification that controls many highly regulated, biological processes that are vital to maintaining cell homeostasis (Duan & Pagano et al., 2021). Ubiquitylation is involved in protein degradation, altering kinase activity, and interfering with protein interactions and dysregulation of the ubiquitin system has been associated with the initiation and development of cancer (Mansour., 2018; Duan & Pagano et al., 2021). In this study, we will focus on the role of DCAF15, an E3 ubiquitin protein, and its role in the promotion of pro-pathogenic pathways that lead to the development of Acute Myeloid Leukemia also known as AML.
1 Broadside. 48"W x 36"H
Kalamazoo, Mich. : Kalamazoo College
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