Gastrointestinal Permeability of Model Solutes and Halofuginone in the 7-14 Day Old Chicken
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Authors
Oelslager, Barbara A.
Issue Date
1991
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
In this study, we developed a useful method for determining the
absorption kinetics of model permeants and coccidiostats in the chick
intestine. The transport barrier of the aqueous boundary layer was
quantified and found to be similar in terms of its impact on the absorption
of at least one lipophilic permeant (salicylic acid) to that already
characterized in the rat. Baseline data was generated on the absorption of
halofuginone, an important non-polyether coccidiostat, against which
other coccidiostats and experimental compounds can be compared. The
present study was also a first step toward defining characteristics of the
chicken intestine which are essential to the eventual development of a
comprehensive model for predicting the behavior of drugs in this system.
Future studies should address such issues as drug absorption by the
epithelium of the ceca, regional variations in drug residence times,
comparisons of halofuginone with polyether ionophore coccidiostats (e.g.
monensin), and the influence of coccidial infection on absorptive
properties of the chick intestine.
Description
vi, 50 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.