Construction and Characterization of Helicobacter pylori tRNA-guanine transglycosylase (TGT) in pET28a His-tagged vector

dc.contributor.advisorGarcia, George A.
dc.contributor.authorHurt, Blake P.
dc.date.accessioned2009-04-13T16:14:38Z
dc.date.available2009-04-13T16:14:38Z
dc.date.issued2005-04-29
dc.description.abstractHelicobacter pylorus is a gram-negative, microaerophilic, spiral-shaped bacterium that colonizes the human stomach and infects more than 50% of the human population. Given the high number of clinical cases this bacterium is responsible for, it is a surprise that H. pylorus has yet to be fully characterized. Part of the problem with providing one comprehensive DNA sequence is that H. pylori has a very high mutation rate. TGT is an essential enzyme in the queuine biosynthetic pathway, a pathway that exchanges guanine for the modified nucleoside queuine in the wobble position of tRNAs with anticodon sequence GUN. This pathway serves as a potential target for antibiotic treatment, as it is not found in humans.en
dc.description.sponsorshipUniversity of Michigan
dc.description.sponsorshipCollege of Pharmacy, University of Michigan
dc.description.sponsorshipDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2005
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10920/8046
dc.language.isoen_USen
dc.publisherKalamazoo, Mich. : Kalamazoo College.en
dc.relation.ispartofKalamazoo College Diebold Symposium Presentations Collection
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleConstruction and Characterization of Helicobacter pylori tRNA-guanine transglycosylase (TGT) in pET28a His-tagged vectoren
dc.typePresentationen
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