Home Drug Testing Kit: The Stability of Drugs and Metabolites in Urine During Incubation at 37 °C
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Authors
Rivera, Juliet
Issue Date
1998
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The stability of drugs and metabolites in urine was investigated for the
development of a D.O.A. (Drugs of Abuse) home testing kit. The objectives were
to maintain the drug levels in the urine specimens at least 4-7 days through the
mailing process and throughout a broad range of temperatures, to find the best
sample container for shipment and storage purposes, and to determine if
preservative tablets will be needed to stabilize the drugs in the urine.
Drug positive urine samples were incubated at 37°C for four weeks and
tested on different days for ethanol, amphetamines, cocaine, cannabinoids, PCP,
and opiates using the Abbott TDx instrument system to run the clinical assays.
Four different sample container and two different kinds of preservative tablets
were evaluated to detect if one maintained the stability of the drug levels in the
urine better than another.
Completion of the studies indicated that all the drugs, except cocaine and
PCP, showed stability of at least 7 days with or without preservatives at 37°C.
To prevent cocaine metabolites, cannabinoids, and ethanol levels from declining
over time, 420 mg of Boric Acid (Cult-ur) tablets was needed to keep these drug
levels stable. There was no differences between the four sample containers
evaluated throughout the study. The Corning/Samco bottles were chosen to be
used in the drug home-testing kit because these bottles were easiest to handle.
Description
vi, 32 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.