The Neuroprotective Effects of RS-127445 in a Glutamate Excitotoxicity Model of Caenorhabditis elegans

dc.contributor.authorKeramidas, Christina
dc.date.accessioned2022-04-06T14:54:44Z
dc.date.available2022-04-06T14:54:44Z
dc.date.issued2018
dc.description1 Broadside. 48"W x 36"Hen_US
dc.description.abstractNeurodegenerative diseases are characterized by neuronal impairment or death Glutamate excitotoxicity is a neuronal death pathway involved in many neurodegenerative diseases1 Glutamate excitotoxicity occurs when extracellular glutamate concentrations rise and are sustained beyond normal levels2 Current clinical treatment options for glutamate excitotoxicity are not viable long term solutions3 Serotonin (5-HT) has been shown to modulate glutamate excitotoxicity indicating modulation of 5-HT receptors might be an approach to reduce glutamate excitotoxicity4 Previous research in this lab has shown in a Caenorhabditis elegans (C. elegans) glutamate excitotoxicity loss of SER-1 reduces the number of necrotic neurons per animal (Figure 1). SER-1 is the ortholog to the human 5-HT2 receptor familyen_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2018en_US
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://cache.kzoo.edu/handle/10920/43373
dc.language.isoen_USen_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleThe Neuroprotective Effects of RS-127445 in a Glutamate Excitotoxicity Model of Caenorhabditis elegansen_US
dc.typePresentationen_US
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