The Neuroprotective Effects of RS-127445 in a Glutamate Excitotoxicity Model of Caenorhabditis elegans
Loading...
Authors
Keramidas, Christina
Issue Date
2018
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Neurodegenerative diseases are characterized by neuronal
impairment or death
Glutamate excitotoxicity is a neuronal death pathway
involved in many neurodegenerative diseases1
Glutamate excitotoxicity occurs when extracellular
glutamate concentrations rise and are sustained beyond
normal levels2
Current clinical treatment options for glutamate
excitotoxicity are not viable long term solutions3
Serotonin (5-HT) has been shown to modulate glutamate
excitotoxicity indicating modulation of 5-HT receptors might
be an approach to reduce glutamate excitotoxicity4
Previous research in this lab has shown in a Caenorhabditis
elegans (C. elegans) glutamate excitotoxicity loss of SER-1
reduces the number of necrotic neurons per animal (Figure
1).
SER-1 is the ortholog to the human 5-HT2 receptor family
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.