The Neuroprotective Effects of RS-127445 in a Glutamate Excitotoxicity Model of Caenorhabditis elegans
Neurodegenerative diseases are characterized by neuronal impairment or death Glutamate excitotoxicity is a neuronal death pathway involved in many neurodegenerative diseases1 Glutamate excitotoxicity occurs when extracellular glutamate concentrations rise and are sustained beyond normal levels2 Current clinical treatment options for glutamate excitotoxicity are not viable long term solutions3 Serotonin (5-HT) has been shown to modulate glutamate excitotoxicity indicating modulation of 5-HT receptors might be an approach to reduce glutamate excitotoxicity4 Previous research in this lab has shown in a Caenorhabditis elegans (C. elegans) glutamate excitotoxicity loss of SER-1 reduces the number of necrotic neurons per animal (Figure 1). SER-1 is the ortholog to the human 5-HT2 receptor family
1 Broadside. 48"W x 36"H
Kalamazoo, Mich. : Kalamazoo College
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