Investigation of the Sulfide Contraction Sequence for Synthesizing 2-Amino-4-Quinolones
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Authors
Krueger, Mary C.
Issue Date
1988
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Quinalones have over the years gained attention as a
class of antibacterial agents (Albrecht, 1977). A
tremendous amount of synthetic research is aimed at
improving the performance of these compounds. The C02H
group at the 3 position is considered essential, as well as
a fluorine atom at the 7 position, although many
modifications on the skeleton have been explored (Schentag
and Domagala, 1985). Few studies involving substitution at
the 2 position have been conducted (Schentag and Domagala,
1985). One recent study (Chu et al., 1985) concluded that
substitution of a sulfur atom at the 2 position could lead
to useful compounds. The purpose of this project is to
investigate the use of the sulfide contraction sequence in
preparing starting materials for the synthesis of
quinalones, in particular those with amino substituents at
the C2 position.
Description
iv, 26 p.
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