A Clinical Study of an Automated Regional Citrate Anticoagulation Protocol in Patients with Severe Renal Failure
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Authors
Bae, Alexander J.
Issue Date
2010
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Regional citrate anticoagulation (RCA) in sustained, low-efficiency, dialysis
(SLED), has been found to be a more safe and effective alternative to hemodialysis.
The Division of Nephrology and Hypertension at Henry Ford Hospital Main Campus
has derived protocols for the automated delivery of calcium in RCA-SLED from
computer models. A clinical study of these protocols has been carried out to
evaluate the safety, efficacy, and efficiency of the RCA-SLED protocol in 48 patients
displaying acute kidney injury (AKI) or chronic kidney disease (CKD). Safety was
evaluated by analyzing maintenance of critically important systemic concentrations
of hemoglobin and ionized calcium. Effectiveness of RCA-SLED was evaluated by
analyzing pre- and post-treatment levels of urea clearance. Efficiency was evaluated
by analyzing the performance of t.he dialyzer during this clinical study. The results
conclude that RCA-SLED is a safe, effective, and efficient means of renal replacement
therapy (RRT) and automation is feasible. Auto'mation, however, would not be
capable without the use of complex, multivariable computer models.
Description
vi, 31 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.