Serotonin 2C Receptor Function in the Central Nervous System: An Autoradiographic Study
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Authors
Garlits, John E.
Issue Date
1998
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
5-HT2C is a critical, widely distributed receptor in the CNS whose dysfunction may play a key role in many diseases including depression, anxiety, eating disorders, sexual dysfunction, and Parkinson's Disease. The Sokoloff method for [C14]2-DG Autoradiography was utilized to measure the physiological effects of a preferential 5-HT2C agonist and a selective 5-HT2C antagonist (S8 242084) in the discrete structures in the rat brain. The results support that S8 242084 may prove a useful antidepressant, analgesic, or treatment for Parkinson's Disease that is
not likely anxiogenic.
Description
vi, 53 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.