Effects of Methamphetamine in the Motor Striatum of Mice
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Authors
Erbe, Jeff K.
Issue Date
2003
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Determining the mechanism by which methamphetamine effects striatal functioning is an
important goal in attaining further insight for the neuronal effects of methamphetamine
and exact processes by which neurotoxicity occurs. The present experiment is a
preliminary study that used a terminal deoxynucleotidyl transferase-mediate dUTP nick
end labeling [TUNEL] kit to identify cell death, due to methamphetamine, in three
distinct regions of mouse striatum This was observed in both adult and developing mice
pups. Pregnant female mice were injected with either 20-mg/kg or 30-mg/kg body
weight amounts of methamphetamine hydrochloride for I 0 days during pregnancy and
the brains tissue samples were taken from their pups at days PIO (10 days after birth),
P30, and then as adults. Results showed most cell death occurred in rostral striatum. The
P30 mice revealed significantly more cell death than P10 and adult mice.
Description
v, 30 p.
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College.
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.