The Characterization of Dicer 1 and Ago 2 in Eutopic and Ectopic Endometrium in the Olive Baboon ( Papio anubis) Incoculated with Endometriosis

dc.contributor.authorJanowiak, Eric M.
dc.date.accessioned2022-04-01T14:18:20Z
dc.date.available2022-04-01T14:18:20Z
dc.date.issued2019
dc.description1 Broadside. 48"W x 36"Hen_US
dc.description.abstractEndometriosis is a gynecological disease that is characterized by the presence of endometrial tissue outside the uterine cavity . This disease causes chronic inflammation, intense pain , and in many instances leads to infertility among women . The pathogenesis of endometriosis is still unknown. However, m icroRNA had been shown to play critical roles in many gynecological disorders including endometriosis, thus, this study aims to determine the expression profiles of the mechanistic proteins (AGO 2 and Dicer 1 ) behind microRNA biogenesis. Results revealed aberrant levels of AGO 2 protein in glandular endometrial cells between tissue types. The role AGO 2 has in microRNA biogenesis, in context with our results, suggest that it plays a critical part in the expression of genes involved with apoptosis and other responses associated with endometriosis , likely contributing to the pathophysiology of the disease. Our results for Dicer 1 were inconclusive.en_US
dc.description.sponsorshipKalamazoo College. Department of Biology. Diebold Symposium, 2019en_US
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://cache.kzoo.edu/handle/10920/43310
dc.language.isoen_USen_US
dc.publisherKalamazoo, Mich. : Kalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Diebold Symposium Presentation Collectionen
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.en
dc.titleThe Characterization of Dicer 1 and Ago 2 in Eutopic and Ectopic Endometrium in the Olive Baboon ( Papio anubis) Incoculated with Endometriosisen_US
dc.typePresentationen_US
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