The Characterization of Dicer 1 and Ago 2 in Eutopic and Ectopic Endometrium in the Olive Baboon ( Papio anubis) Incoculated with Endometriosis
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Authors
Janowiak, Eric M.
Issue Date
2019
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
Endometriosis is a gynecological disease that is characterized by the
presence of endometrial tissue outside the uterine cavity . This disease
causes chronic inflammation, intense pain , and in many instances leads
to infertility among women . The pathogenesis of endometriosis is still
unknown. However, m icroRNA had been shown to play critical roles in
many gynecological disorders including endometriosis, thus, this study
aims to determine the expression profiles of the mechanistic proteins
(AGO 2 and Dicer 1 ) behind microRNA biogenesis. Results revealed
aberrant levels of AGO 2 protein in glandular endometrial cells between
tissue types. The role AGO 2 has in microRNA biogenesis, in context
with our results, suggest that it plays a critical part in the expression of
genes involved with apoptosis and other responses associated with
endometriosis , likely contributing to the pathophysiology of the disease.
Our results for Dicer 1 were inconclusive.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.