Examining the Neuroprotective Effects of 7-hydroxy-2-(2-phenylethyl)chromone in a Glutamate Excitotoxicity model of C. Elegans
Neurodegenerative diseases affect about 50 million Americans each year. Glutamate excitotoxicity is a pathway that plays a role in neuronal death across several neurodegenerative diseases through the toxic influx of calcium. Caenorhabditis elegans (C. elegans) have been used as a model system for human diseases due to its sensory and neuromuscular system. Yoon et al. found 5-HPEC to have neuroprotective effects in rat cortical cells. Driscoll et al. have shown that ZB1102 strain is a good model of glutamate excitotoxicity due to the influx of glutamate in the synapse that affects neurophysiology in C. elegans. Previous studies have shown that 5-HPEC has a significant neuroprotective effect against glutamate excitotoxicity in ZB1102 animals. 7-HPEC has been isolated from natural sources and is structurally related to 5-HPEC. The neuroprotective activity of 7-HPEC has not yet been investigated.
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