Modulation of Free Radical – Scavenging Pathways in Response Passive Stretch Training in Mice
Loading...
Authors
Thompson, Kathleen
Issue Date
2008
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
• Muscle injury generated by lengthening contractions has damaging effects
including pain, muscle weakness, and decreased range of motion in patients
ranging from athletes to the elderly.
• Training with various types of exercise (passive stretch, isometric contractions,
and prior training with lengthening contractions) has been shown to protect
skeletal muscle from such injury.
• Passive stretch training is of particular interest because it provides protection to
skeletal muscle in adult and elderly mice and is non-damaging.
• Recent research has revealed that reactive oxygen species are produced by
skeletal muscle during non-damaging contractions as well as during damaging
contractile activity, suggesting that free radicals may play some role in the
induction of adaptive responses to contractile activity.
• We hypothesized that passive stretch training protects skeletal muscle from
lengthening contraction-induced muscle injury through endogenous modifications
in free radical scavenging pathways, particularly via increases in activities of two
key antioxidant enzymes, superoxide dismutase (SOD) and catalase.
• Thus, our goal was to determine whether administering a protocol of passive
stretches known to provide protection from subsequent lengthening contractioninduced
muscle injury resulted in increased SOD and catalase activity levels.
Description
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College.
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.