The Effects of TUC-73, TUC-74 and (+)-Cyanidanol-3 on Ischemic/Reperfusion Damage in Isolated Rabbit Hearts
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Authors
DeWitt, Coleen C.
Issue Date
1990
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Myocardial infarction, or heart attack, is the leading cause
of death in America today. Myocardial ischemia, which is a
reduction in coronary flow such that the oxygen supply to the
myocardium is not adequate to supply the oxygen demands of the
tissues, is often the cause of this fatal event. The damage
associated with ischemia and reperfusion (the return of flow)
has been attributed to many factors. In these experiments,
the Langendorff isolated rabbit heart model was used to
examine the effects of two novel chemical entities, TUC-73 and
TUC-74, on the heart after it was subjected to 30 min. of
global ischemia. (+)-Cyanidanol-3 (Catechin), which was
previously found to be protective against ischemic/reperfusion
injury, was used as a reference compound. TUC-73 and (+)Cyanidanol-
3 both exhibited dose response effects. TUC-73 was
the most effective, while TUC-74 failed to have any
significant effects. Based upon these results, these
compounds and structurally similar compounds will be tested
in vivo and will undergo biochemical testing to determine the
mechanisms of action.
Description
iv, 39 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.