In Vitro Effects of (-)-Epigallo-3-Catechin Gallate on Induced Inflammation Response in Human Gingival Fibroblasts and EpiGingival TM Tissue Models

Abstract

Periodontal diseases such as gingivitis can lead to more severe diseases, which may end with tooth loss Characterized by inflammation, redness, and bleeding Drugs are designed to inhibit production of pro-inflammatory proteins. Antibiotics may not be wise due to developing resistant strains of bacteria Bacteria  Macrophages ChemokinesNeutrophils The goal is to find natural agents for managing and suppressing symptoms, such as inflammation, in patients with these diseases Green tea contains polyphenoliccatechins, which have shown to inhibit inflammation pathways in many cell lines (Haqqiet al., 1999; Kim et al., 2006)