JavaScript is disabled for your browser. Some features of this site may not work without it.
  • About K
  • Academics
  • Admission
  • Alumni Relations
  • Giving to K
  • News & Events
  • Student Life
  • HORNET HIVE
  • ATHLETICS
  • SITEMAP
  • WEBMAIL
    • Login
    View Item 
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item

    Effects of Acute Exposure to Titanium Dioxide on Endothelial Function

    Thumbnail
    View/Open
    poster presentation (245.3Kb)
    Date
    2009
    Author
    Westphal, Joslyn
    Metadata
    Show full item record
    Abstract
    Nanotechnology, the manipulation and manufacturing of particles less than 100 nm in size, is at the forefront of scientific research.  However, there is evidence that the size-dependent properties of nanoparticles may increase their toxicity.  Studies have shown that short-term (24 hr) exposure to nanomaterials, including titanium dioxide (TiO2), is associated with increased reactive oxygen species (ROS) production. Previous work has suggested that this increase in ROS production may involve cellular internalization. However, we hypothesized that nanomaterials interact with the endothelial cell surface resulting in an impaired endothelial-dependent vasodilation.  Experiments were performed using the isolated saline-perfused rat lung.  The pulmonary vasculature was exposed to TiO2 (0.05% V/V or 0.1% V/V) for 1 hr.  Endothelial function was assessed using graded doses of an endothelial-dependent vasodilator (ionomycin; 0.03 - 1.0 µM), administered luminally.  Ionomycin induced a dose-dependent vasodilation.  There were no statistically significant differences in the vasodilatory response to ionomycin between vehicle and TiO2 treated lungs. These results suggest that acute TiO2 exposure does not alter endothelial-dependent vasodilation in the rat pulmonary vasculature. 
    URI
    http://hdl.handle.net/10920/8310
    Collections
    • Diebold Symposium Posters and Schedules [479]

    Browse

    All of CACHECommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV
    Logo

    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602

    About K
    Academics
    Admission
    Alumni Relations
    Giving to K
    News & Events
    Student Life
    Sitemap
    Map & Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official disclaimer
    Search this site


    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar
    DSpace Express is a service operated by 
    Atmire NV