Design and Synthesis of a New Heteroditopic Ligand
Wytko, Jennifer A.
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While macrocyclic molecules have been studied for years, the chemistry of macropolycyclic molecules is a relatively new, yet rapidly advancing field. One particular reason for interest in macropolycycles is their intramolecular cavity, defined by the molecular subunits, which may contain various binding sites. These sites allow for the formation of inclusion complexes and the binding of numerous guests, including substrates, inorganic metal cations, organic or biological molecular cations. inorganic or organic molecular anions, and neutral substrates. Macropolycycles may be monotopic, single site receptors, or polytopic, multisite receptors, and may thus form respectively, mononuclear or polynuclear complexes. While monotopic complexes are useful in studying molecular recognition processes, receptor chemistry, and molecular catalysis, polytopic complexes also provide insight concerning regulation, cooperativity and allostery, which represent higher forms of molecular behavior.