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dc.contributor.advisorStrohbach, Joseph W.
dc.contributor.authorGottler, Lindsey M.
dc.date.accessioned2008-09-25T13:55:02Z
dc.date.available2008-09-25T13:55:02Z
dc.date.issued2001
dc.identifier.urihttp://hdl.handle.net/10920/6046
dc.description.abstractThe initial goal ofthe research project was to reproduce the preliminary results by resynthesizing the novel ring system 3-(benzyl)-7-fluoro-l-[(lZ,3Z)-1 ,3-pentadienyl]-2,3dihydropyrimido[ 5,4-c]quinolin-4(lH)-one. Once reproducibility was achieved, optimization ofthe reaction was studied. The parameters in question were the reaction time, temperature and the solvent system. The optimization ofthe reaction then allowed for full characterization ofthe final product. In addition, by monitoring the reaction during optimization the reaction mechanism ofthe transformation was explored. The final goal was then to consider various substituents on the benzyl group attached to the amide nitrogen. Specifically, a para-bromo and a nitro group were favored for added mass and electron density in comparison to the original para-chloride previously prepared. The addition ofthe heavier bromide atom was anticipated to improve upon xray crystallography data. Alternatively, the nitro group may impart improved crystallinity and perhaps higher quality crystal structures would be available. During the initial preparations ofthe dihydropyrimido quinolinone crystal structures were obtained revealing a four-molecule arrangement per cell. The p-bromo product resulted in increased crystal quality and similar crystal arrangement. The p-nitro product was unable to be crystallized with using the acetonitrile solvent system.en
dc.language.isoen_USen
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.en
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.subject.lcshHeterocyclic compounds
dc.titleSynthesis and Characterization of the Novel Heterocyclic Ring System: dihydropyrimido quinolin-oneen
dc.typeThesisen


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  • Chemistry Senior Individualized Projects [860]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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