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dc.contributor.advisorLaursen, Sandra L.
dc.contributor.advisorZhao, Zhiyang
dc.contributor.authorBergeron, Laura B.
dc.description.abstractWilliam Porter has pointed out that hydrophilic antioxidants tend to be more effective in bulk oil systems and lipophilic antioxidants tend to be more effective in oil-water emulsions, this is called the Polar Paradox. Edwin Frankel explains this paradox on the basis of an antioxidant's ability to move to an oil-air or oil-water interface. He has done many experiments comparing carnosic acid, carnosol, and rosmarinic acid in bulk oil and oilwater emulsion systems. In this study compounds were prepared that have much more closely related antioxidant structures and differ primarily in their hydrophilicity. The compounds prepared were the methyl ester and octyl ester of caffeic acid. The methyl ester is more hydrophilic and the octyl ester is more lipophilic. The antioxidant effectiveness of the compounds were evaluated in bulk oil and oil-water emulsions using conjugated diene hydroperoxide values and headspace GC hexanal analysis. It was found that the results of this study tended to support the "Polar Paradox" suggested by Porter.en
dc.description.sponsorshipPharmacia and Upjohn, Inc. Drug Metabolism Research (Kalamazoo, MI)
dc.relation.ispartofseriesSenior Individualized Projects. Chemistry.en
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.subject.lcshParkinson's disease
dc.titleIn Vitro Metabolism of PNU-95666en

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  • Chemistry Senior Individualized Projects [827]
    This collection includes Senior Individualized Projects (SIP's) completed in the Chemistry Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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