The Cardiovascular Effects of Impurities in Clandestinely Produced Methamphetamine in Rats
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The use of methamphetamine has skyrocketed in the United States over the last decade. The national Drug Enforcement Agency seizes hundreds of clandestine laboratories that produce this chemical, and to the manufacturer, the consequence does not seem to outweigh the profit. An investment of only $100, could produce over $10,000 worth of methamphetamine, and the starting materials can be bought at a local supermarket. The negative side to this, however, is the painful withdrawal, the rapid addiction, and the permanent damage to both the cardiovascular and the nervous system. Most laboratory research done with methamphetamine, is done with a pure unadulterated product, manufactured in nationally standardized biochemical or pharmaceutical companies. The effects of the clandestinely produced impurities are ignored in these studies. This experiment investigates the cardiovascular effect of these impurities found in a popular recipe used by underground manufacturers. The results show that the cardiovascular effects of these impurities differ from those of the purified methamphetamine. The drug effects different binding sites, and therefore, may have distinct chronic results. Scientific knowledge of these impurities is important to research for emergency treatment of an overdose, as well as curing a long term addiction.