A Casein Kinase 1 Epsilon Single Nucleotide Polymorphism and Acute Response to Caffeine in Humans

Abstract

•Recently, mouse studies identified a quantitative trait locus (QTL) on chromosome 15 containing the (mouse) Csnk1e gene that has been linked to cocaine and methamphetamine sensitivity (Jones et al., 1999; Palmer et al., 2005). •Veenstra-VanderWeele and colleagues investigated three single nucleotide polymorphisms (SNPs) in the CSNK1E gene. One of these SNPs, rs135745, was significantly correlated to heightened sensitivity to the subjective effects of d-amphetamine (Veenstra-VanderWeele et al., 2006). •The SNP rs135745 flanks the CSNK1E gene on chromosome 22 in a noncoding region 3 kb 3’ of the 3’-UTR of CSNK1E. It likely does not directly influence drug sensitivity, but instead serves as a molecular marker that associates with some mutation that may affect CSNK1E activity