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dc.contributor.advisorWetzler, Lee M.
dc.contributor.authorJorth, Peter Allan
dc.description1 broadside : ill.
dc.descriptionDiebold Scholar
dc.description.abstract•Neisseria meningitidis is a Gram negative pathogenic bacteria responsible for bacterial meningitis and sepsis. During infection the bacteria release lipooligosaccharide (LOS), a component of the outer membrane of the bacteria. These components then activate the cells of the immune system through a variety of receptor molecules. •As signaling continues downstream of the TLRs the mitogen-activated protein kinases (MAPKs) become involved through a phosphorylation cascade. MAPKs are responsible for regulating mitosis, apoptosis, cell movement, metabolism, and gene expression. •There are three principle MAPK subfamilies including the extracellular signal-regulated kinases (ERK), the c-Jun-NH2-terminal kinases (JNK), and p38 enzymes. •Ultimately, a group of intercellular signaling molecules called cytokines are activated. Of particular interest are the pro-inflammatory cytokines TNFa and IL-6, which have been found to regulate apoptosis during infection in addition to regulating antibody production in B cells, respectively. •Porins, small pore molecules covering the surface of the bacterial cell membrane have also become of interest because of the implication of neisserial porin as a potent immune adjuvant. •Through looking at the effects of MAPK inhibitors on cytokine production in murine macrophage cells stimulated with different TLR ligands (LOS, neisserial porin B (PorB), and Pam3CSK) this study will elucidate more of the signaling events that lead to the efficacy of PorB as a potent adjuvanten
dc.description.sponsorshipBoston Medical Center
dc.description.tableofcontentsIntroduction -- Materials and methods -- Results -- Discussion -- Acknowledgments
dc.publisherKalamazoo College
dc.titleMAP Kinase Inhibition Prevents Induction of IL-6 and TNFα by Porin B of Neisseria meningitidis in Murine Macrophagesen

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  • Diebold Symposium Posters and Schedules [444]
    Poster and oral presentations by senior biology majors that include the results of their Senior Individualized Projects (SIPs) at the Diebold Symposium. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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