Towards the Synthesis of Neuroprotective Dictyoquinazol Derivatives

Abstract

The need for more efficacious neuroprotective pharmacophores has been in high demand during recent years with 795,000 people suffering from strokes every year in the United States alone. Dictyoquinazols may help lead to the answer of this demand as they have proven neuroprotective capabilities as seen in recent studies. These studies, however, are rather limited thus making this an area of research that needs to be looked into on a greater scale. This study looks deeper into the synthesis of Dictyoquinazol derivatives in an attempt to produce new neuroprotective compounds by working towards the synthesis of 2,6, and 4′ substituents. The reduction reactions of nitro benzaldehydes have also proven effective with yields upwards of 64%. The initial synthesis of quinazolinone derivatives has proven effective and leads to decently high yields with both phenyl (42-74%) as well as methyl (76-100%) substituents on carbon 6. Further synthetic analysis has proven difficult while attempting to convert the oxazinone moiety to that of a pyrimidinone while not only ensuring this substitution occurs but also verifying the recyclization of the pyrimidinone.