Determination of Telomeric Protein Interaction Binding Sites Between Amino Acids 58-268 of TRF1 and 224-276 of TIN2 and Between Amino Acids 42-245 of TRF2 and 203-361 of TIN2
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Telomerase: • A ribonucleoprotein complex, with RNA and protein components, in all eukaryotes • Required for lengthening the ends of telomeric DNA by reverse transcriptase Without Telomerase: • Unable to lengthen chromosomes, DNA shortens with each replication • Results in the loss of genetic information and greater susceptibility to mutation Unknown: • The exact amino acid interactions of the telomeric proteins • The nature of the interaction between certain telomeric proteins The Study will: • Examine the relations of three telomeric proteins, TRF1, TRF2, and TIN2 • Attempt to form complexes with protein fragments of decreasing size (Figure 1) • Examine the interaction between TRF1 and TRF2 • Lead to greater understanding concerning telomeric protein binding
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Determination of telomeric protein interaction binding sites between amino acids 58-268 of TRF1 and 224-276 of TIN2 and between amino acids 42-245 of TRF2 and 203-361 of TIN2 Anstett, Danielle (Kalamazoo College, 2006)Interactions of telomeric protein-protein complexes have important implications in the development of diseases such as cancer. Approximately 90% of all cancer cases are associated with the reactivation of telomerase ...