Examining the Neuroprotective Effects of 7-hydroxy-2-(2-phenylethyl)chromone in Glutamate Excitotoxicity model of C. Elegans
MetadataShow full item record
There are 600 neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) that are affecting about 50 million Americans each year. Glutamate excitotoxicity is a pathway that plays a role in neuronal death and degeneration across several neurodegenerative diseases. In the Williams’ lab, 5-HPEC has proven to have neuroprotective activity. Because 5-HPEC and 7-HPEC are a subclass of 2-(phenylethyl)chromone, this study examines if 7-Hydroxy-2- (2-phenylethyl)chromone (7-HPEC) will have the same properties and neuroprotective effects in C. elegans as their family compounds. Developed in the Driscoll lab, a glutamate excitotoxicity model of C. elegans was used to prove the effects of 7-HPEC. The results indicated that although 7-HPEC does not have a significant impact on neuroprotective effects in a C. elegans glutamate excitotoxicity model, there is a decrease due to its effects but is not comparable to its 5-HPEC. 7-HPEC had limited effects when quantifying the number of necrotic neurons.