JavaScript is disabled for your browser. Some features of this site may not work without it.
  • About K
  • Academics
  • Admission
  • Alumni Relations
  • Giving to K
  • News & Events
  • Student Life
  • HORNET HIVE
  • ATHLETICS
  • SITEMAP
  • WEBMAIL
    • Login
    View Item 
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item
    •   CACHE Homepage
    • Academic Departments, Programs, and SIPs
    • Biology
    • Diebold Symposium Posters and Schedules
    • View Item

    Lovastatin Can Be Used To Produce Non-prenylated ykt6 From PC12 Cells

    Thumbnail
    View/Open
    poster presentation (95.67Kb)
    Date
    2004
    Author
    Bimber, Benjamin N.
    Metadata
    Show full item record
    Abstract
    • SNARE Proteins are involved in membrane fusion • ykt6 is a v-SNARE of unknown function in the cell • Expressed at high levels in neurons, suggesting specific function in brain. • ykt6 exists in two pools in the cell: membrane bound and free, cytosolic protein. • Contains 2 domains, the SNARE binding motif (which contains the CCAIM prenylation site) and amino-terminal (NT) domain which is involved in localization of the protein. • Membrane bound protein can bind to other SNAREs to form SNARE complexes, while cytosolic cannot. The mechanism behind this is unknown. •We hypothesize that the addition of a prenyl group (a small hydrophobic fatty acid) results in a conformational change in the cytosolic form, rendering it inactive. • To test this, PC12 cells were treated with the drug lovastatin, which inhibits prenylation and purified non-prenylated ykt6 tested for SNARE binding activity.
    URI
    http://hdl.handle.net/10920/4385
    Collections
    • Diebold Symposium Posters and Schedules [444]

    Browse

    All of CACHECommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV
    Logo

    Kalamazoo College
    1200 Academy Street
    Kalamazoo Michigan 49006-3295
    USA
    Info 269-337-7000
    Admission 1-800-253-3602

    About K
    Academics
    Admission
    Alumni Relations
    Giving to K
    News & Events
    Student Life
    Sitemap
    Map & Directions
    Contacts
    Directories
    Nondiscrimination Policy
    Consumer Information
    Official disclaimer
    Search this site


    Academic Calendars
    Apply
    Bookstore
    Crisis Response
    Employment
    Library
    Registrar
    DSpace Express is a service operated by 
    Atmire NV