Effects of environmental agents on bacteria from the oral cavity
Drake, Daniel R.
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Current cancer research links Helicobacter pylori with stomach cancer and the genus Neisseria with nuclei aberrations in the oral cavity. In a similar model, preliminary results of a recent study (Mager et al, 2002) showed that Capnocytophaga gingivalis and Prevotella melaninogenica were associated with oral cancer lesions, alluding to a possible role its development. The aim of this project was to test the susceptibility of these two oral bacteria to benzo[a]pyrene (B[a]P), a potent carcinogen found in cigarette smoke to test for the production of carcinogenic by-products. In a separate study, the bacteria were exposed to curcumin, a polyphenolic compound found in plant foods with antimicrobial and anti-cancer properties.