Evaluating Mass Spectrometry as a Potential Early Ovarian Cancer Recurrence Detection Method Using Bottom-Up Proteomic Analysis of Biomarker CA125 (MUC16)
Loading...
Authors
Schroeder, Lia A.
Issue Date
2022
Type
Presentation
Language
en_US
Keywords
Alternative Title
Abstract
High-grade serous ovarian cancer (HGSOC) is a common, recurring form of
ovarian cancer, currently detected using a double-determinant
immunoassay. This method analyzes resurging levels of the cancer
biomarker CA125, which constitutes <1% of the larger mucin protein,
MUC16, contained within a tandem repeat section (Figure 1). While the
current detection method is effective and widely used, applying targeted
mass spectrometry could allow for more accurate and reliable
identification and quantification of low abundance proteins, such as
MUC16 from small samples.
Description
1 Broadside. 48"W x 36"H
Citation
Publisher
Kalamazoo, Mich. : Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.