Investigation of the Juvenile Hormone nuclear receptor as target forFMRFamide and SCP
Bielang, Rebecca E.
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• Juvenile Hormone (JH) is a hormone found in insects. It is crucial to their development in both larval and adult life cycles. • JH needs a nuclear receptor in order to act. Many researchers have looked for this elusive and important receptor without any successful results. • Flies with apterous (AP) gene mutations have a pleitotropic phenotype. They lack wings; more importantly, they lack FMRFamide and SCP expression in thoracicventral (Tv) neurons. • The regulatory sequences that drive the Drosophila FMRFamide gene expression to the Tv cells have been shown to contain binding sites for AP. • A previous study showed that increasing apterous expression resulted in an increase of JH, which in turn caused the FMRFa expression to be rescued.