Broad-Scale Identification of White Matter Proteins and their Differential Expression in CADASIL

Abstract

This Study: There were two hypotheses for this study: 1) We would identify a novel list of proteins preferentially expressed in the white matter of the brain; 2) we expected to see diminished levels of protein expression in the white matter of CADASIL brains compared to controls. Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease that causes damage to the small penetrating vessels in the white matter of the brain. This leads to recurrent strokes, subcortical infarcts, eventually resulting in degeneration of the white matter. As such, it was thought that the expression levels of proteins in these damaged regions of the white matter would be diminished. However, very little research has focused on the discovery of proteins specific to the white matter.